This guide supports entrepreneurs in opening a professional bank account in Luxembourg. It explains banks’ due diligence obligations under AML/CFT law, requiring identification documents, a detailed business questionnaire, and verification of beneficial owners. Entrepreneurs are advised to separate personal and business assets, provide transparent information (including business plans), and maintain open communication with their banker. A clear, complete application facilitates approval, while banks must ensure ongoing monitoring of activities. The guide stresses preparation, transparency, and collaboration as keys to building a strong, lasting relationship with financial partners, ensuring compliance and supporting business growth in Luxembourg’s ecosystem.